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Table 3 Comparison of each treatment outcomes The response rate in regard to penile curvature angle did not change by treatment (p=0.154)

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While the emergence of amyloids may have begun as early as LUCA [84], the existence of a proteostasis-defending heat shock response system that arose around the same time implies that this relationship is not only evolutionarily conserved but should also be robust and effective [154]

Whether the recently established robust dipsogenic response to brain sst 2 activation (Karasawa et al., 2014) also contributes to the increased feeding behavior (Kissileff, 1969) inhibited by stress will have to be further investigated

Besides, several putative inherited disorders related to folate metabolism are described in the literature, for instance: DHFR deficiency, cellular uptake defects, and 5,10-methyleneTHF cyclohydrolase deficiency (part of the trifunctional enzyme 5,10-methyleneTHF dehydrogenase 1 MTHFD1 )